Experimental study on the effect of Coumarone resin on the performance of SBS-modified asphalt.

An inexpensive and high-performing solid Coumarone resin was added to Styrene-butadiene-styrene (SBS) copolymer-modified asphalt to enhance its storage stability and road performance. To assess the effect of Coumarone resin dosage on the SBS-modified asphalt, a series of laboratory tests were conducted. The composite modified asphalt's segregation test was used to evaluate its storage stability, Dynamic Shear Rheometer (DSR) and Multiple Stress Creep Recovery (MSCR) tests were employed to investigate its high-temperature performance and permanent deformation resistance, and the Bending Beam Rheology (BBR) test was utilized to measure its low-temperature performance. Fluorescence microscopy was used to observe the composite modified asphalt's microstructure, and Fourier Transform Infrared Spectroscopy (FTIR) was conducted to study the changes in chemical structure during the modification process. The results showed that Coumarone resin can improve the compatibility of SBS and asphalt, improve the high-temperature performance and deformation resistance of SBS-modified asphalt, and adding an appropriate amount of Coumarone resin can help enhance the low-temperature cracking resistance of modified asphalt. The optimal dosage of Coumarone resin recommended for SBS-modified asphalt performance enhancement is 2% under the test conditions, as determined by comparing the test results of samples with various dosages.

Changing epidemiologic patterns of typhus group rickettsiosis and scrub typhus in China, 1950-2022.

OBJECTIVES: We conducted a systematic analysis of the notifiable rickettsial diseases in humans in China during 1950-2022. METHODS: We utilized descriptive statistics to analyze the epidemiological characteristics, clinical manifestations, and diagnostic characteristics of typhus group rickettsiosis (TGR) and scrub typhus (ST) cases. RESULTS: Since the 1950s, there have been variations in the incidence rate of TGR and ST in China, with a downtrend for TGR and an uptrend for ST. The South became a high-incidence area of TGR, whereas the North was previously the high-incidence area. ST cases were concentrated in the South and the geographic area of ST spread northward and westward. The seasonality of TGR and ST were similar in the South but distinct in the North. Most TGR and ST cases were reported by county-level medical institutions, whereas primary institutions reported the least. Delayed diagnosis was associated with fatal outcomes of TGR and ST. Cases in low-incidence provinces, confirmed by laboratory tests and reported from county/municipal-level institutions had higher odds of delayed diagnoses. CONCLUSIONS: Our study revealed significant changes in the epidemiological characteristics of TGR and ST in China, which can provide useful information to enhance the control and prevention strategies of rickettsial diseases in China.

Spatiotemporal effects of meteorological conditions on global influenza peaks.

BACKGROUND: Numerous studies have suggested that meteorological conditions such as temperature and absolute humidity are highly indicative of influenza outbreaks. However, the explanatory power of meteorological factors on the seasonal influenza peaks varied widely between countries at different latitudes. OBJECTIVES: We aimed to explore the modification effects of meteorological factors on the seasonal influenza peaks in multi-countries. METHODS: Data on influenza positive rate (IPR) were collected across 57 countries and data on meteorological factors were collected from ECMWF Reanalysis v5 (ERA5). We used linear regression and generalized additive models to investigate the spatiotemporal associations between meteorological conditions and influenza peaks in cold and warm seasons. RESULTS: Influenza peaks were significantly correlated with months with both lower and higher temperatures. In temperate countries, the average intensity of cold season peaks was stronger than that of warm season peaks. However, the average intensity of warm season peaks was stronfger than of cold season peaks in tropical countries. Temperature and specific humidity had synergistic effects on influenza peaks at different latitudes, stronger in temperate countries (cold season: R2=0.90; warm season: R2=0.84) and weaker in tropical countries (cold season: R2=0.64; warm season: R2=0.03). Furthermore, the effects could be divided into cold-dry and warm-humid modes. The temperature transition threshold between the two modes was 16.5-19.5 °C. During the transition from cold-dry mode to warm-humid mode, the average 2 m specific humidity increased by 2.15 times, illustrating that transporting a large amount of water vapor may compensate for the negative effect of rising temperatures on the spread of the influenza virus. CONCLUSION: Differences in the global influenza peaks were related to the synergistic influence of temperature and specific humidity. The global influenza peaks could be divided into cold-dry and warm-humid modes, and specific thresholds of meteorological conditions were needed for the transition of the two modes.

Effects of pollen concentration on allergic rhinitis in children: A retrospective study from Beijing, a Chinese megacity.

With global climate change and rapid urbanization, the prevalence of allergic diseases caused by pollen is rising dramatically worldwide with unprecedented complexity and severity, especially for children in mega-cities. However, because of the lack of long time-series pollen concentrations data, the accurate evaluation of the impact of pollen on allergic rhinitis (AR) was scarce in the Chinese metropolis. A generalized additive model was used to assess the effect of pollen concentration on pediatric AR outpatient visits in Beijing from 2014 to 2019. A stratified analysis of 10 pollen species and age-gender-specific groups was also conducted during the spring and summer-autumn peak pollen periods separately. Positive associations between pollen concentration and pediatric AR varied with the season and pollen species were detected. Although the average daily pollen concentration is higher during the spring tree pollen peak, the influence was stronger at the summer-autumn weed pollen peak with the maximum relative risk 1.010 (95% CI 1.009, 1.011), which was higher than the greatest relative risk, 1.003 (95% CI 1.002, 1.004) in the spring peak. The significant adverse effects can be sustained to lag10 during the study period, and longer in the summer-autumn peak (lag13) than in the spring peak (lag8). There are thresholds for the health effects and they varied between seasons. The significant effect appeared when the pollen concentration was higher than 3.74 × 105 grain·m-2·d-1 during the spring tree pollen peaks and 4.70 × 104 grain·m-2·d-1 during the summer-autumn weed pollen peaks. The stratified results suggested that the species-specific effects were heterogeneous. It further highlights that enough attention should be paid to the problem of pollen allergy in children, especially school-aged children aged 7-18 years and weed pollen in the summer-autumn peak pollen period. These findings provide a more accurate reference for the rational coordination of medical resources and improvement of public health.

Impacts of meteorological factors on the risk of scrub typhus in China, from 2006 to 2020: A multicenter retrospective study.

Scrub typhus is emerging as a global public health threat owing to its increased prevalence and remarkable geographic expansion. However, it remains a neglected disease, and possible influences of meteorological factors on its risk are poorly understood. We conducted the largest-scale research to assess the impact of meteorological factors on scrub typhus in China. Weekly data on scrub typhus cases and meteorological factors were collected across 59 prefecture-level administrative regions from 2006 to 2020. First, we divided these regions into 3 regions and analyzed the epidemiological characteristics of scrub typhus. We then applied the distributed lag nonlinear model, combined with multivariate meta-analysis, to examine the associations between meteorological factors and scrub typhus incidence at the total and regional levels. Subsequently, we identified the critical meteorological predictors of scrub typhus incidence and extracted climate risk windows. We observed distinct epidemiological characteristics across regions, featuring obvious clustering in the East and Southwest with more even distribution and longer epidemic duration in the South. The mean temperature and relative humidity had profound effects on scrub typhus with initial-elevated-descendent patterns. Weather conditions of weekly mean temperatures of 25-33°C and weekly relative humidity of 60-95% were risk windows for scrub typhus. Additionally, the heavy rainfall was associated with sharp increase in scrub typhus incidence. We identified specific climatic signals to detect the epidemic of scrub typhus, which were easily monitored to generalize. Regional heterogeneity should be considered for targeted monitoring and disease control strategies.

Influence of Urbanization on the Spatial Distribution of Associations Between Air Pollution and Mortality in Beijing, China.

This study investigated the influence of urbanization on the intra-city spatial distribution of associations between air pollution and mortality in Beijing, China. First, we utilized the generalized additive model to establish the exposure-response associations of PM2.5, O3, with nonaccidental and cardiorespiratory mortality between urban and suburban areas. Second, we assessed district-specific air pollution-related mortality and analyzed how these associations were affected by the degree of urbanization. Finally, we analyzed the changes in air pollution-related mortality before and after the enforcement of the Air Pollution Prevention and Control Action Plan (referred to as the Action Plan). The effect estimates of PM2.5 for nonaccidental mortality were 0.20% (95% CI: 0.12-0.28) in urban areas and 0.46% (95% CI: 0.35-0.58) in suburban areas per 10 µg/m3 increase in PM2.5 concentrations. The corresponding estimates of O3 were 0.13% (95% CI: -0.04-0.29) in urban areas and 0.34% (95% CI: 0.12-0.56) in suburban areas per 10 µg/m3 increase in O3 concentrations; however, the difference between the estimates of O3 in urban and suburban areas was not statistically significant. The district-specific results suggested that the estimated risks increased along with urban vulnerability levels for the effects of PM2.5. Implementing the Action Plan reduced the mortality risks of PM2.5, but the risks of O3 increased in some districts. However, the difference in the estimates between the pre- and post-emission reductions was not statistically significant. Our study indicated that populations living in less urbanized areas are more vulnerable to the adverse effects of air pollution in Beijing, particularly for PM2.5.

Identification of Health Effects of Complex Air Pollution in China.

After the Chinese government introduced a series of policies to strengthen the control of air pollution, the concentration of particulate matter has decreased, but the concentration of ozone has increased, and the problem of complex air pollution still exists, posing a serious threat to public health. Therefore, disentangling the health effect of multi-pollutants has been a long-discussed challenge in China. To evaluate the adverse effects of complex air pollution, a generalized additive model was used to assess the health risks of different pollution types in eight metropolises in different climates in China from 2013 to 2016. Instead of directly introducing multiple pollutant concentrations, we integrated the concentration levels of PM2.5, NO2, and O3 into a set of predictors by grouping methods and divided air pollution into three high single-pollutant types and four high multi-pollutant types to calculate mortality risk in different types. The comprehensive results showed that the impact of high multi-pollutant types on mortality risk was greater than that of high single-pollutant types. Throughout the study period, the high multi-pollutant type with high PM2.5, NO2, and O3 and the high multi-pollutant type with high PM2.5 and NO2 were more associated with death, and the highest RRs were 1.129 (1.080, 1.181) and 1.089 (1.066, 1.113), respectively. In addition, the pollution types that most threaten people are different in different cities. These differences may be related to different pollution conditions, pollutant composition, and indoor-outdoor activity patterns in different cities. Seasonally, the risk of complex air pollution is greater in most cities in the warm season than in the cold season. This may be caused by the modifying effects of high temperature on pollutants in addition to different indoor-outdoor activity patterns in different seasons. The results also show that calculating the effect of individual air pollutants separately and adding them together may lead to an overestimation of the combined effect. It further highlights the urgency and need for air pollution health research to move towards a multi-pollutant approach that considers air pollution as a whole in the context of atmospheric abatement and global warming.

The influences of the East Asian Monsoon on the spatio-temporal pattern of seasonal influenza activity in China.

Previous research has extensively studied the seasonalities of human influenza infections and the effect of specific climatic factors in different regions. However, there is limited understanding of the influences of monsoons. This study applied generalized additive model with monthly surveillance data from mainland China to explore the influences of the East Asian Monsoon on the spatio-temporal pattern of seasonal influenza in China. The results suggested two influenza active periods in northern China and three active periods in southern China. The study found that the northerly advancement of East Asian Summer Monsoon (EASM) influences the summer influenza spatio-temporal patterns in both southern and northern China. At the interannual scale, the north-south converse effect of EASM on influenza activity is mainly due to the converse effect of EASM on humidity and precipitation. Within the annual scale, influenza activity in southern China gradually reaches its maximum during the summer exacerbated by the northerly advancement of EASM. Furthermore, the winter epidemic in China is related to the low temperature and humidity influenced by the East Asian Winter Monsoon (EAWM). Moreover, the active period in transition season is related partially to the large rapid temperature change influenced by the transition of EAWM and EASM. Despite the delayed onset and instability, the climatic condition influenced by the East Asian Monsoon is one of the potential key drivers of influenza activity.

Chemical characterization, source apportionment, and health risk assessment of PM2.5 in a typical industrial region in North China.

To clarify the chemical characteristics, source contributions, and health risks of pollution events associated with high PM2.5 in typical industrial areas of North China, manual sampling and analysis of PM2.5 were conducted in the spring, summer, autumn, and winter of 2019 in Pingyin County, Jinan City, Shandong Province. The results showed that the total concentration of 29 components in PM2.5 was 53.4 ± 43.9 µg·m-3, including OC/EC, water-soluble ions, inorganic elements, and metal elements. The largest contribution was from the NO3- ion, at 14.6 ± 14.2 µg·m-3, followed by organic carbon (OC), SO42-, and NH4+, with concentrations of 9.3 ± 5.5, 9.1 ± 6.4, and 8.1 ± 6.8 µg·m-3, respectively. The concentrations of OC, NO3-, and SO42- were highest in winter and lowest in summer, whereas the NH4+ concentration was highest in winter and lowest in spring. Typical heavy metals had higher concentrations in autumn and winter, and lower concentrations in spring and summer. The annual average sulfur oxidation rate (SOR) and nitrogen oxidation rate (NOR) were 0.30 ± 0.14 and 0.21 ± 0.12, respectively, with the highest SO2 emission and conversion rates in winter, resulting in the SO42- concentration being highest in winter. The average concentration of secondary organic carbon in 2019 was 2.8 ± 1.9 µg·m-3, and it comprised approximately 30% of total OC. The concentrations of 18 elements including Na, Mg, and Al were between 2.3 ± 1.6 and 888.1 ± 415.2 ng·m-3, with Ni having the lowest concentration and K the highest. The health risk assessment for typical heavy metals showed that Pb poses a potential carcinogenic risk for adults, whereas As may pose a carcinogenic risk for adults, children, and adolescents. The non-carcinogenic risk coefficients for all heavy metals were lower than 1.0, indicating that the non-carcinogenic risk was negligible. Positive matrix factorization analysis indicated that coal-burning emissions contributed the largest fraction of PM2.5, accounting for 35.9% of the total. The contribution of automotive emissions is similar to that of coal, at 32.1%. The third-largest contributor was industrial sources, which accounted for 17.2%. The contributions of dust and other emissions sources to PM2.5 were 8.4% and 6.4%, respectively. This study provides reference data for policymakers to improve the air quality in the NCP.

Projections of future temperature-related cardiovascular mortality under climate change, urbanization and population aging in Beijing, China.

Climate change is causing the surface temperature to rise and the extreme weather events to increase in frequency and intensity, which will pose potential threats to the survival and health of residents. Beijing is facing multiple challenges such as coping with climate change, urbanization, and population aging, which puts huge decision-making pressure on decision maker. However, few studies that systematically consider the health effects of climate change, urbanization, and population aging for China. Based on the distributed lag nonlinear model (DLNM) and 13 global climate models in the Coupled Model Intercomparison Project Phase 6 (CMIP6), this study obtained the temporal and spatial distribution of surface temperature through statistical downscaling methods, and comprehensively explored the independent and comprehensive effects of urbanization and population aging on the projection of future temperature-related cardiovascular disease (CVD) mortality in the context of climate and population change. The results showed that only improving urbanization can reduce future temperature-related CVD mortality by 1.7-18.3%, and only intensified aging can increase future temperature-related CVD mortality by 48.8-325.9%. Taking into account the improving urbanization and intensified aging, future temperature-related CVD mortality would increase by 44.1-256.6%, and the increase was slightly lower than that of only intensified aging. Therefore, the intensified aging was the biggest disadvantage in tackling climate change, which would obviously magnify the mortality risks of temperature-related CVD in the future. Although the advancement of urbanization would alleviate the adverse effects of the intensified aging population, the mitigation effects would be limited. Even so, Urbanization should be continued to reduce health risks for residents. These findings would contribute to formulate policies related to mitigate climate change and reduce baseline mortality rate (especially the elderly) in international mega-city - Beijing. In addition, relevant departments should improve the medical health care level and optimize the allocation of social resources to better cope with and adapt to climate change.

Assessment of black carbon exposure level and health economic loss in China.

Based on the geographic information system (GIS) software and the application of the black carbon (BC) and fine particulate matter ([Formula: see text]) ratio method, this paper analyzed and calculated the national BC distribution from 2015 to 2017 and evaluated the national human exposure to BC. The results showed that from 2015 to 2017, 2/3 of the national land area and nearly half of the population were exposed to 1-3 [Formula: see text], and the area and population exposed to a concentration less than 2 [Formula: see text] increased yearly, while the area and population exposed to a concentration higher than 9 [Formula: see text] decreased yearly. The estimated economic loss showed that 77.3% of the targeted districts or counties claimed a loss per square kilometer of 50 million Chinese Yuan (CNY) or less from the perspective of annual changes, and districts and counties in Beijing-Tianjin-Hebei and Hunan with annual losses between 50 and 500 million CNY showed an increasing trend. The BC ratio (the proportion of BC economic loss to GDP) of Beijing-Tianjin-Hebei and Hunan also showed an increasing trend yearly.

Development of GRAPES-CUACE adjoint model version 2.0 and its application in sensitivity analysis of ozone pollution in north China.

We presented the development of the gaseous chemistry adjoint module of the meteorological-chemical model system GRAPES-CUACE (Global/Regional Assimilation and PrEdiction System coupled with CMA Unified Atmospheric Chemistry Environmental Forecasting System) on the basis of the previously constructed aerosol adjoint module. The latest version of the GRAPES-CUACE adjoint model mainly includes the adjoint of the physical and chemical processes, the adjoint of the transport processes, and the adjoint of interface programs, of both gas and aerosol. The adjoint implementation was validated for the full model, and adjoint results showed good agreement with brute force sensitivities. We also applied the newly developed adjoint model to the sensitivity analysis of an ozone episode occurred in Beijing on July 2, 2017, as well as the design of emission-reduction strategies for this episode. The relationships between the ozone concentration and precursor emissions were well captured by the adjoint model. It is indicated that for a case used here, the Beijing peak ozone concentration was influenced mostly by local emissions (6.2-24.3%), as well as by surrounding emissions, including Hebei (4.4-16.8%), Tianjin (1.8-6.6%), Shandong (1.8-2.6%), and Shanxi (<1%). In addition, reduction of NOx, VOCs, and CO emissions in these regions would effectively decrease the Beijing peak ozone concentration. This study highlights the capability of GRAPES-CUACE adjoint model in quantifying "emission-concentration" relationship and in providing guidance for environmental control policy.

[Similarities and Differences of Valley Winds in the Beijing Plain and Yanqing Areas and Its Impact on Pollution].

Under certain terrain and weather conditions, mountain-valley circulation is one of the main meteorological factors affecting aerosol pollution in plain-mountain area. Based on environmental monitoring data and multi-source meteorological data for the Beijing-Tianjin-Hebei region between 2015 and 2019, the characteristics, similarities, and differences of mountain-valley winds in the Beijing Plain and Yanhuai Basin regions were compared. The results show that the mountain-valley winds recorded at the Beijing Observatory are from southwest to northeast compared to from the southeast to northeast at Yanqing station. With the aggravation of pollution levels, the mountain-valley wind intensity decreased by 17.7%-32.4%. When the wind speed at Beijing Observatory was 2-6 m·s-1, the maximum PM2.5 concentration in southeast was 83 µg·m-3, which was higher than in the southwest. When the wind speed at the Yanqing station was 2-6 m·s-1, the PM2.5 concentrations in SE-SSE area was 20-40 µg·m-3 higher than in other directions, and the concentrations in the valley winds were 10-12 µg·m-3 higher than the average value for the last five years. Taking the typical heavy pollution event on March 5-8, 2015, as an example, the influence of mountain-valley winds is mainly reflected in the high humidity and regional transmission of southeast winds during the valley wind stage. The PM2.5 concentrations at the Yanqing station increased by 100-130 µg·m-3 during the valley wind stage on March 6 and 7, 2015. The inversion temperature developed to 1000 m during the mountain wind stage, the local dew point at the Beijing Observatory and the Yanqing station rose by approximately 18℃. The peak dew point at the Yanqing station occurring 2 hours after the Beijing Observatory, and the concentrations of PM2.5 rose slightly under high humidity conditions. Meanwhile, the thermal gradient between the 400-m-high Yanqing Station and Yudu Mountain gradually decreased, and the mountain-valley wind decreased by 8% and 6%, respectively. The weakening of local circulation may be related to the bidirectional feedback mechanism of the boundary layer and high concentrations of aerosols.

Polycyclic aromatic hydrocarbons induce endothelial injury through miR-155 to promote atherosclerosis.

Polycyclic aromatic hydrocarbons (PAHs) are considered as an external factor that induces atherosclerotic cardiovascular disease. Although miR-155 is known to be involved in cardiovascular disease, whether it is involved in PAH-induced arteriosclerosis remains unclear. We evaluated the effects of PAHs on vascularization, permeability, and miR-155 expression in HUVECs. We found that PAHs-induced sclerosis of HUVECs was characterized by increasing permeability, decreasing proliferation, and vascular lumen number. The expression of miR-155 was upregulated by PAHs treatment, and transfection with miR-155 inhibitor could reverse above effect of PAHs-induced sclerosis. Meanwhile, transcriptome sequencing revealed that 63 genes were downregulated in the group of PAHs treatment alone, and were then upregulated in the miR-155 inhibitor group. These genes were mainly involved in complement and coagulation cascades, cytokine-cytokine receptor interaction, TNF signaling pathway, and NF-kappa B signaling pathway. Among these 63 genes, SERPIND1 was directly targeted and regulated by miR-155. Further in vivo experiments in ApoE-/- mice confirmed that PAH accelerates the development of arteriosclerosis by promoting the expression of miR-155 to downregulate the SERPIND1. Therefore, PAH exaggerates atherosclerosis by activating miR-155-dependent endothelial injury. This study provides a fundamental insight on the miR-155 mechanism for PAHs enhancing atherosclerosis and miR-155 potentially serving as a novel drug target.

Impact of the pandemic of COVID-19 on emergency attendance for stroke and acute myocardial infarction in Beijing, China.

To estimate the impact on emergency attendance for stroke and acute myocardial infarction (AMI) during the pandemic of COVID-19 in Beijing, China. Based on 17,123 and 8693 emergency attendance for stroke and AMI, an interrupted time-series (ITS) study was conducted. Since 01/24/2020, the top two levels of regulations on major public health have been implemented in Beijing. This study covered from 03/01/2018 to 06/03/2020, including 19 weeks of lockdown period and 99 weeks before. A segmented Poisson regression model was used to estimate the immediate change and the monthly change in the secular trend of the emergency attendance rates. The emergency attendance rates of stroke and AMI cut in half at the beginning of the lockdown period, with 52.1% (95% CI 45.8% to 57.7%) and 63.1% (95% CI 56.1% to 63.1%) immediate decreases for stroke and AMI, respectively. Then during the lockdown period, 7.0% (95% CI 2.5%, 11.6%) and 16.1% (95% CI 9.5, 23.1) increases per month in the secular trends of emergency attendance rates were shown for stroke and AMI, respectively. Though the accelerated increasing rates, there were estimated 1335 and 747 patients with stroke and AMI without seeking emergency medical aid during the lockdown, respectively. The emergency attendance for stroke and AMI cut in half at the beginning of the pandemic then had gradual restoration thereafter. The results hint the need for more engagement and communications with all stakeholders to reduce the negative impact on CVD emergency medical services during the crisis.

[Influence of Meteorological Conditions on Ozone Pollution at Shangdianzi Station Based on Weather Classification].

As a typical secondary pollutant, tropospheric ozone has become the primary pollutant in Beijing in spring and summer, and meteorological factors are one of the main factors affecting the change in concentration. Using atmospheric composition and meteorological observation data from 2008 to 2017, the weather types in Beijing were divided into six categories by Lamb classification and Mann-Whitney U test. Among these, the mean and extreme values of ozone concentration of SWW and C types at Shangdianzi station were the highest, and the highest frequency was from April to September, with a total of 47.4%. The main contribution weights of the two types were determined by a multiple stepwise regression equation. The southwest wind prevailed in 54.0% of SWW and C types, and the newly discharged pollutants and secondary aging air masses were continuously transported by the southwest air flow. The vertical velocity zero layer appeared near 850 hPa. The horizontal and vertical meteorological conditions were conducive to the transport, accumulation, and secondary generation of ozone. The northeast wind prevailed in 64.7% of AN and ESN types, and the air masses source was clean. The same subsidence movement and air divergence prevailed above 1000 hPa. The discharged pollutants can also be diluted and diffused quickly, and the ozone concentration was at a low value. Taking the NW type on May 3, 2015 as an example, although the northwest air flow prevailed on the ground, with clean source, the residual high concentration of ozone above the boundary layer was transported to the near ground through the vertical subsidence of the atmosphere, resulting in the high concentration of ozone on some days.

Impacts of urbanization on the temperature-cardiovascular mortality relationship in Beijing, China.

The effect of temperature on cardiovascular disease (CVD) mortality has been extensively studied. However, it remains largely unknown over whether there is any difference between urban and suburban areas within the same city and how urbanization modifies the relationship between temperature and CVD mortality. In order to examine whether the association between temperature and CVD mortality existed difference in urban and suburban areas, and how urbanization modified this association, we used a distributed lag nonlinear model and a generalized additive model to investigate temperature-related CVD mortality in urban and suburban areas in Beijing, China, from 2006 to 2011. The age, gender, and educational attainment of the population were stratified to explore the modifying effect. We observed that the impacts of heat and cold temperature on CVD mortality were higher in suburban areas than in urban areas. In addition, the elderly and illiterate subjects in suburban areas were more vulnerable to both heat and cold than their counterparts in urban areas. Moreover, higher urbanization levels were significantly associated with districts having lower the excess risks for temperature- CVD mortality. Our findings provide evidence that populations in suburban Beijing have higher risk of temperature-related CVD mortality than those in urban areas. Therefore, greater attention should be paid to vulnerable groups in suburban areas to reduce temperature-related health burden.

Seasonal variation in health impacts associated with visibility in Beijing, China.

Visibility has been continuously and stably observed for more than half a century, while particulate matter with an aerodynamic diameter ≤ 2.5 µm (PM2.5) was not introduced to the national monitoring system in China until 2013. It is a scientific issue as to whether visibility can be used as an alternative to assess the health risks of air pollution in periods and areas without pollutant monitoring data. A generalized additive model (GAM) was adopted to estimate the impacts of seasonal changes in visibility on mortality in Beijing, China. Moreover, we estimated the contributions of particulate matter in the health effects of visibility by adjusting for dry extinction coefficient (ßdryext) and PM2.5 in the model, respectively. We found that the acute health impacts of visibility varied by season, with the highest risks in winter. For respiratory mortality, the effect estimates per 1 km decrease in visibility were 0.40% (95% CI: 0.17-0.62%) in spring, 0.10% (95% CI: -0.14-0.34%) in summer, 0.27% (95% CI: 0.09-0.45%) in autumn, and 0.62% (95% CI: 0.38-0.85%) in winter. For cardiovascular mortality, the effect estimates per 1 km decrease in visibility were 0.20% (95% CI: 0.08-0.31%) in spring, 0.16% (95% CI: 0.04-0.27%) in summer, 0.25% (95% CI: 0.13-0.37%) in autumn, and 0.24% (95% CI: 0.13-0.35%) in winter. The seasonal pattern of health impacts related to visibility reflected the seasonal variations in the characteristics of air pollution emission sources and meteorological conditions that are unfavorable for pollutant dispersion. Particulate matter, particularly PM2.5, made significant contributions to the health impacts of visibility. The results indicated that controlling pollutant emissions in winter would be of significant importance to improve air quality and mitigate the health hazard of air pollution in Beijing. Our study also provides further evidence on the feasibility of using visibility to assess the health impacts of particulate matter pollution.

Vertical evolution of black carbon characteristics and heating rate during a haze event in Beijing winter.

Black carbon aerosol plays an important role on absorbing shortwave solar radiation. The absorption of BC in urban environment with intensive anthropogenic emissions may modify the atmospheric thermodynamics by heating the planetary boundary layer (PBL), however the exact impacts are still largely uncertain due to lack of in-situ observations. Here we report the detailed in-situ characterization on vertical profiles of BC-related properties including the BC mass, size distribution and mixing state over Beijing by successive flights, during which a full process of haze initialization, development and ceasing were captured and processes of BC properties during this typical haze event was in detail investigated. We found the shallow PBL and the temperature inversion importantly enhanced the BC mass loading in the polluted day and these BC particles were significantly coated with mass ratio of coating over refractory BC increasing from about 1 to 10, whereas when the capping was released the BC was dispersed throughout the column and the coating was reduced. The coatings may cause the enhancement of BC absorption by 95% and introduce additional heating rate as high as 0.1 K/h during hazy day. The absorbing power efficiency and heat rate of BC showed positive vertical gradient during peak pollution, which may enhance the temperature inversion at upper level of the PBL. These results provide impacts of BC mixing state on atmospheric heating, and emphasize the importance of including BC mixing state, especially under highly polluted environment, to model the aerosol-boundary layer interaction over urban environment with high BC emission.